Statistical power was 60% to detect a per allele effect size of 6.0% SD (0.24 cm/year) for PHV1, 6.6% SD (0.10 cm/year) for PHV2, and 4.9% SD (0.46 cm) for adult height, assuming a MAF of 0.31, which was the average among the 48 SNPs, additive genetic model and significance threshold p<0.05. For comparison, we had 80% statistical power to detect a per allele effect size of 7.6% SD (0.30 cm/year) for PHV1, 8.4% SD (0.13 cm/year) for PHV2, and 6.2% SD (0.58 cm) for adult height with the same assumptions. Quanto (version 1.2.3.) [34] was used for the power calculations.
