Chunk #6 — 2 METHODS

Source

RAREMETAL: fast and powerful meta-analysis for rare variants.

Embedded

yes

Text

Meta-analysis is implemented in a separate tool, RAREMETAL, which calculates gene-level burden tests (either weighted or unweighed), variable frequency threshold tests and sequence kernel association tests (SKAT) (Liu et al., 2014). Key formulae can be found in our online documentation (http://genome.sph.umich.edu/wiki/RAREMETAL_METHOD).