During longer-term follow-up, through 52 weeks, no polymorphism was significantly associated with continuous abstinence in the varenicline or placebo treatment groups. However, in the bupropion group, as well as in the three treatment groups combined, continuous abstinence was again associated with several SNPs within CYP2B6 (Table 3), including rs8109525 (p=0.0028, Figure 1b). Several of the polymorphisms tested in CYP2B6 were in LD with this SNP (including rs7260329, described above); however, none of these linked SNPs correspond to functionally described CYP2B6 alleles (Anon, 2008). In the combined treatment group, variants in CYP2A6 were also significantly associated with continued abstinence.
