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Chunk #2 — Introduction

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Altered resting-state EEG source functional connectivity in schizophrenia: the effect of illness duration.
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In schizophrenic patients, altered FC in response to cognitive and sensory paradigms has been demonstrated in all the traditional EEG frequency bands (Pachou et al., 2008; Fujimoto et al., 2013) supporting the hypothesis that electroencephalographic indices of FC may be a useful marker of specific impairment in higher-order processing (see the review of Uhlhaas et al., 2008). Furthermore, EEG-FC in the resting state reflects the activity of interneuron connections and cortical synchronization that are temporally interrupted during specific tasks (Cabral et al., 2014) and has the potential to reveal an a priori intrinsic dysfunctionality which may represent either a state or trait-marker of the schizophrenic condition.