studied in this regard.80 These reward circuits participate independently, and interactively with glutamatergic and GABA-ergic signaling, in the persistence of drug use and the development and maintenance of addiction. However, although there is clear evidence of central nervous system changes in these circuits related to impulsivity, disinhibition and drug use, the molecular mechanism of the action of gene variants in these pathways on specific drugs of addiction requires further consideration.
