Next, we combined the moderation component with the standard Cholesky. Results from this bivariate moderation model are shown in Table 2. The full model for men and women (excluding DZ opposite sex twins, allowing for full sex differences) is presented. Path estimates shown are raw – those estimates where 95% confidence intervals encompass zero could be dropped from the model without a significant of model fit. These non-significant paths included all shared environmental influences on AD symptoms (common and specific) and moderation of the genetic influences specific to AD symptoms in male twins. Therefore, merging information from the moderation model and the Cholesky, the standard bivariate model revealed that genetic influences on age at 1st drink and AD symptoms were partially overlapping and that even after accounting for this overlap, there was evidence for early age at 1st drink increasing variance attributable to heritable factors on AD symptoms – in females, both the overlapping and specific genetic influences were moderated while in males, only those genetic influences that were overlapping between age at 1st drink and AD symptoms were moderated
