Chunk #97 — Online Methods — Power calculation for somatic mutation detection in cancer tissue samples

Source: Absolute quantification of somatic DNA alterations in human cancer.
Embedded: yes

Text

Variants with ≥ k supporting reads are then considered detected. We specified the sequencing error rate ε = 1 × 10−3 and FPR = 5× 10−7 for all computations in this study. Power is then calculated as: