Chunk #18 — Results — eQTL at a common inversion polymorphism on chromosome 17q21 — Identification of gene expression changes in fetal brain associated with neuropsychiatric traits
Reduced expression of one transcript, annotated to the RPL31P12 gene (encoding Ribosomal Protein L31 Pseudogene 12), was associated with major depressive disorder (P-SMR = 2.19 × 10− 6), while increased expression of the RPS26 gene (encoding Ribosomal Protein S26) was associated with genetic risk for anorexia nervosa (P-SMR = 2.34 × 10− 6). Increased expression of the LRRC57 gene, encoding Leucine Rich Repeat Containing 57, was associated with bipolar disorder (P-SMR = 3.07 × 10− 5). In addition, a transcript annotated to GNL3, encoding G Protein Nucleolar 3, was associated with both bipolar disorder (P-SMR = 2.17 × 10− 6) and schizophrenia (P-SMR = 2.71 × 10− 7), with risk alleles for both disorders associated with increased expression of this transcript in fetal brain.
