A meta-analysis of the COGA EA and AA revealed six SNPs in high LD (pair-wise r2>0.9 and 0.7, D’>0.9 and 0.8 in EAs and AAs respectively) were associated with low theta EEG coherence at p<5x10−8 (Table 1, Figure 1, Supplemental Figure 1, q-q plot in Supplemental Figure 6). They are located in AC107892 (ENSG00000266213) a long intergenic non-coding RNA (lincRNA) on 18q23 (Chr 18, 75894847-75900263, hg38). The most significant SNP was rs12954372 (Meta-analyzed p = 9.15E-09; EA p: 1.51x10−5 and AA p: 1.04x10−5; Supplemental Figure 1). The minor allele (A) was associated with increased posterior interhemispheric low theta EEG coherence (Meta-analyzed Z-score: 5.75). rs12954372 was also associated with other highly correlated (r2>0.70) posterior-related coherence measures (Supplemental Table 2) in COGA families, including high theta (5-7 Hz) and the full theta band (3-7 Hz), but these findings did not reach genome-wide significance.
