2A). In addition, global analysis of miR-34a predicted targets showed enrichment of molecular networks related to neuronal development, differentiation and synaptic plasticity as well as gene sets implicated in neurodevelopmental disorders (Tables S3–S742). Taken together, these results validate three genes implicated in BD risk as miR-34a targets and suggest that miR-34a may function to regulate an interacting molecular network important to BD pathogenesis through effects on neurodevelopment.
