The study of GxE relationships has garnered attention and excitement, but also caution and concern5,6. Therefore, we seek to encourage careful and systematic analyses of G–E relationships as an important tool to further our understanding of the complex etiology of AUD and to identify environmental targets for prevention and intervention efforts. Previous papers have outlined recommendations for rigorous GxE research practices (e.g., Dick et al.5). We focus here on the selection of environmental factors that have both theoretical plausibility and empirical precedent for inclusion in the study of G–E relationships.
