The third set of analyses was limited to European-American, alcohol-dependent women. These analyses asked whether CD problems and GABRA2 genotype similarly enhanced the association of obesity with P300. Two separate MANCOVAs were performed on P300a and P300b amplitudes and latencies within anterior and posterior regions. The first MANCOVA examined the effects of CP and OB in a 2 × 2 factorial with age, the total number of alcohol and drug dependence symptoms, and the duration of cigarette smoking as covariates. The remaining MANCOVA substituted GABRA2 genotype for the CP risk factor. Significant effects revealed by the MANCOVAs were further evaluated with univariate ANCOVAs.
