Further studies should explore other alpha thresholds, as well as combining alpha with other electrophysiologic (32, 54) or neurocognitive (55) measures to improve prediction of treatment response. Also, despite evidence that EEG alpha has high reliability and heritability (21–24), few studies have directly examined whether acute or chronic administration of an SSRI alters alpha in depressed patients. A multisite study is now underway assessing neuroimaging, electrophysiologic, and neurocognitive measures before and after one week of SSRI or placebo so as to further examine their differential predictive value.
