multiple testing were not made (Brookes et al. 2004). A post hoc estimate of statistical power based on simulation analysis suggests that with a 0.05 error probability, the observed effect sizes, and a high-risk genotype as common as SNP rs279871 at GABRA2, the sample is adequately powered (>0.80) to detect the observed gender- and genotype-specific effects of daily uplifts (Duncan and Keller 2011; Luan et al. 2001).