Cannabis is the most widely used illegal drug [4] in the United States. Cannabis abuse and dependence are also commonly comorbid with other substance use disorders, particularly smoking [110]. Cannabis use in the United States has increased in recent years, particularly among children and adolescents, raising concern about the effects of exposure on the developing brain. Recently, states such as Colorado have also taken steps to decriminalize cannabis, leading to concerns about the consequences of increased use in children and adolescents as well as adults [111].
