In summary, we report here a large multi-ancestry GWAS and meta-analysis for PAU, in which we focused our analyses in three main directions. First, we demonstrated that there is substantial shared genetic architecture of PAU across multiple populations. Second, we analyzed gene prioritization for PAU using multiple approaches, including cross-ancestry fine mapping, gene-based association, brain-tissue TWAS and fine mapping, and H-MAGMA for chromatin interaction. We identified many genes associated with PAU with biological support, extending our understanding of the brain biology that substantially modifies PAU risk and expands opportunities for investigation using in vitro methods and animal models. These genes are potential targets for downstream functional studies and studies of potential pharmacological intervention based on the drug repurposing results. Third, we investigated the genetic relationship between PAU and many traits, which was possible in populations of AFR ancestries for the first time.
