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Chunk #23 — Results

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Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
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different across sessions and time points (Figure 3B). Rs472402 falls within the first intron of the gene SRD5A1, which codes for an enzyme that converts progesterone to allopregnanolone, among other functions [51]. The minor allele frequency of this SNP in our sample was 48.6%; the HWE P-value was 0.305. The genome-wide P-values for this factor are shown in Figure 3C, and their distribution compared with the P-values under the null (obtained via permutations) is shown in Figure 3D. Differences in the factor values for the three genotypes are shown in Figure 3E. The unprocessed phenotypic data stratified by genotype at this SNP is shown in Figure 3F. Repeated measures ANOVAs were run to determine which individual phenotypes were associated with rs472402.