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Chunk #22 — DISCUSSION

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Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample.
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extend to the more complex phenotype of TS+OCD+ADHD, which is highly heritable, and may in fact be an appropriate alternate phenotype for genetic studies. On the clinical side, the association between maternal ADHD and offspring ADHD and/or OCD is of particular interest, particularly when counseling TS-affected families about potential risks to offspring. However, these results are preliminary, and the complex relationship between these disorders requires further investigation to have clear clinical relevance.