AJUBA belongs to a group of cell adhesion complexes. It is involved in cell fate determination (34) and is an important regulator of the WNT signalling pathway (35). As well as being associated with the number of teeth at 12 months/15 months, the variant rs997154 was also associated with G-men distance (i.e. distance from the glabella to the mid-endocanthion point), suggesting that this gene might be pleiotropically involved in other aspects of craniofacial development besides dentition.
