The pattern of association in published GWAS findings for schizophrenia (and particularly their replication) has been highly variable. Although these studies have shown little support for the results of either other GWAS or prior studies, sample sizes in many cases have not been adequate to deliver reasonable power. In this case, although the discovery sample was somewhat small, the replication sample has reasonable power to detect effects in the ranges modeled. Additional results from a number of large, better powered studies and from meta-analyses of more than 10,000 cases and controls (which have substantial power to detect effects of the kind expected in schizophrenia) are expected in the near future. These results will be critical in determining which of the early results are widely supported. In conclusion, however, our results from the present study of ZNF804A and schizophrenia in a large, ethnically homogeneous sample add further support for the association of the A allele at rs1344706 with schizophrenia.
