across the genome and in low linkage disequilibrium (LD) (r2<0.004) [42], we estimated the genetic profile of the study participants compared with individuals of known ethnic origins (the Caucasian, African and east-Asian individuals genotyped by the HapMap project). We excluded 34 individuals because of some evidence of ethnic admixture (Figure S3), indicating that the extent of admixture within the central Europe and ARCAGE study centers is limited.
