performed a ‘locus wide association study’ testing all SNPs in the MAPT region for association with MAPT transcript expression levels. SNPs in r2 = 1.0 with rs393152 constituted the peak of the association signal (p < 1.0 ×10−8) with MAPT transcript expression levels (Figure 4). We also evaluated the relationship between SNPs in LD with rs393152 and transcript levels of other chromosome 17 genes within the larger MAPT region that were available within GSE15222. 16 As illustrated in Supplemental Figures 3a–f, SNPs in LD with rs393152 did not demonstrate significant association with transcript levels of other genes within the MAPT region further illustrating the specificity of our MAPT findings.
