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Chunk #37 — Discussion

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Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.
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tagged by common variants and where the effect of the minor allele on expression is relatively large. It is also important to note that in the present study, we limited our analysis to transcripts within a relatively narrow (0.5 MB) window around each SNP. This is larger than the average distance between SNP and associated transcript of 121 Kb (Gibbs et al., 2010) but may inadvertently omit true eQTLs at larger distances while maintaining power. Larger series would be needed to expand the analyses to more distal effects.