involve many false positives, care should be used in determining the thresholds, and a careful evaluation of statistical power should be used to determine the goals of the study, such as specifying a desired minimum effect size. When the evidence for association boils down to a single SNP and all its LD proxies, the P-values are all nearly identical and so biological prioritization becomes particularly attractive. This kind of prioritization strategy allows investigators to maximize the return on resources while implementing their specific biological priorities.
