Chunk #29 — Results — Normalization of Kcnj6 dose fails to impact working memory in the Y-maze but normalized exploratory activity

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Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.

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Y-maze testing also allows for an assessment of exploratory activity. The number of arm entries during the test was markedly increased in Ts65Dn:Kcnj6+++ vs. 2N:Kcnj6++ mice (F1,14 = 2.49; p = 0.013) (Fig 4B, red vs. blue). However, no increase was evident comparing Ts65Dn:Kcnj6++− vs. 2N:Kcnj6++ mice (F1,46 = 0.47; p = 0.32) (Fig 4B, green vs. blue). Thus, reducing Kcnj6 gene dose normalized this facet of exploratory behavior in Ts65Dn mice.