SNPs that surpassed the significance threshold of p = 1.0 × 10−6 in the GWAS discovery dataset were assessed for their potential to affect gene expression using the information in the Genotype-Tissue Expression Portal (GTEx)24 (http://www.gtexportal.org) and Braineac25 (http://www.braineac.org/). GTEx links SNP genotype to gene expression in multiple human tissues, whereas Braineac incorporates expression data for multiple brain regions derived from 130 individuals from the UK Brain Expression Consortium (UKBEC) and contains expression-altering SNP information for each brain region.
