the above finding that Nrf2 may be the common regulator which contributes to the up-regulation of CYP2A5 in liver injuries induced by structurally irrelevant pathogenesis. Our data also showed that in Nrf2-null mice, the increase of CYP2A5 induced by hepatic FA accumulation was inhibited but the hepatocellular damage was enhanced which indicated that CYP2A5 up-regulation does not contribute to the development of the HFD-induced liver damage.
