Chunk #23 — Introduction — 1. Epigenetic Regulation due to Histone Covalent Modifications — 1D. Alcohol and Histone Acetylation and Deacetylation Mechanisms in Non-neuronal Tissues
The above examples from both central and peripheral tissues reveal that histone acetylation and deacetylation changes, by bringing about dynamic regulation of gene transcription, provide a mechanism by which alcohol may alter the transcriptome, leading to altered neuronal plasticity and predisposition to addictive behaviors and the associated morbidity.
