The baseline information has been, and will continue to be, extended in several ways. For example, repeat assessments are planned to be conducted in subsets of the cohort every few years, to enable calibration of measurements, adjustment for regression dilution, and estimation of longitudinal change. Objective measures of physical activity have also been collected (using a tri-axial accelerometer) in 100,000 participants in 2013–20148 with repeated measures being collected over a period of a year (on a seasonal basis) from 2,500 of these participants. A multi-modal imaging assessment is currently underway, which comprises magnetic resonance imaging (MRI) of the brain9, heart10 and body, carotid ultrasound11 and a whole body dual-energy X-ray absorptiometry of the bones and joints12. Data collection started in 2014 and is anticipated to take 7–8 years to achieve imaging for 100,000 participants in dedicated imaging assessment centres across the United Kingdom, with repeat imaging measures being planned for a subset of participants.
