nNos PDZ domain and prevents the coupling of nNos activation with NMDA-receptor-mediated calcium influx (Jaffrey et al. 1998). nNos knockout mice have been shown to have an increase in ethanol consumption (Spanagel et al. 2002). Direct sequencing confirmed that a non-synonymous SNP in Nos1ap has the correct haplotype structure. The question of whether this SNP is functionally relevant remains to be determined.
