were unknown (extended family not evaluated); note, however, that we typically genotyped only one proband per family, as well as parents, even if the family were multiplex. Proband distribution by gender was 84% male and 16% female; 58.6% attained a strict research diagnosis of autism; and, based on genetic analysis, 88% of subjects were of European ancestry (Supplementary Material, Fig. S1). Table 1.Number of families (number of probands) used for analysisGroupAGP DiscoveryAGRECombinedPrimary analysisSpc|All1369 (1385)595 (1086)1887 (2394)Str|All809 (812)431 (687)1181 (1440)Spc|Eur1217 (1230)440 (783)1603 (1959)Str|Eur718 (720)311 (485)984 (1160)Exploratory analysesSpc|Verbal897 (909)476 (702)1314 (1552)Spc|Non-Verbal453 (454)295 (375)731 (812)IQ > 80561 (564)—a—IQ < 70279 (281)——Spc, spectrum; Str, strict; All, all ancestries; Eur, European ancestry.aWe could not derive an assessment of IQ for the AGRE data that would be comparable to that from the AGP.
