In summary, this family-based GWAS demonstrated two genome-wide significant associations, one of a polymorphism in an olfactory receptor with the persistent desire or inability to cut down on alcohol consumption, and the other with a sodium leak channel and the high-risk latent class trait. These results validate the advantage of defining a more homogenous sample in which to analyze genetic associations. These results combined with those of other recent studies (Kang et al., 2012; Wang et al., 2012) also demonstrate the valuable resource of the densely affected European American families of COGA.
