Chunk #44 — P2X Receptors and Functions in the CNS — P2X7 Receptor and Functions in the CNS — [11C] PET radioligands of P2X7R

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Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications.

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Even though [11C]SMW139 did not detect overexpression of the P2X7 R in postmortem brain of patients with AD,210,211 this PET radioligand has entered clinical evaluation in patients with MS and is currently the first in human to study neuroinflammation in patients with MS.210,212