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Chunk #18 — MATERIALS AND METHODS — Multilocus tests in the CHRNA5-CHRNA3-CHRNB4 cluster

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Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
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The full logistic model has the form ln(P1−P)=α+β1g+β2s+β3G1+β4G2, where G1 codes genotype status at rs16969968 with a recessive model (determined from the best model analysis) and G2 codes the second SNP with the primary, log-additive model. We test for the effect of each SNP by removing it from the model and calculating the likelihood ratio chi-square with one df.