other lead variants were both imputed. Imperfect imputation could be an additional source of noise obfuscating the signal from rs671. In this case we know the major risk variant; it is a well-validated and well known functionally-null allele. Without that prior information, these results could have been taken to support distant SNPs mapping to different genes. For MAXDRINKS, the p-value for the lead SNP is over two orders of magnitude stronger than that for the putative functional SNP, rs671.
