Chunk #35 — 4. Discussion — 4.1 Confirmation and Extension of Previous Findings

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Psychopathology in offspring from multiplex alcohol dependence families with and without parental alcohol dependence: a prospective study during childhood and adolescence.

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Multiplex ascertainment appears to lead to increased segregation of susceptibility genes and their intermediate phenotypes (Smalley et al., 2000). A clustering of childhood traits (ADHD, CD, and ODD) appear to be associated with adult alcohol dependence in unselected samples (Earls et al., 1988; Reich et al., 1993; Merikangas and Avenevoli, 2000; Clark et al., 2004) and in samples derived from multiplex ascertainment (Kuperman et al., 1999; Ohannessian et al., 2004).