Genes with significant genetic (p < 0.05), partial (p < 0.05), and literature correlations (r > 0.3) were then selected for gene set enrichment analysis. After removing Riken clones, intergenic sequences, predicted genes, and probes not associated with functional mouse genes, the remaining list of correlates with mean hippocampal expression levels above baseline were uploaded to Webgestalt (http://bioinfo.vanderbilt.edu/webgestalt/) for gene ontology (GO) and pathway analyses [32]. The p-values from the hypergeometric test were automatically adjusted to account for multiple comparisons using the Benjamini and Hochberg correction [33]. Categories with an adjusted p-value of less than 0.05 indicated that the set of submitted genes was significantly over-represented in those categories.
