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Chunk #0 — Introduction

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High frequencies of de novo CNVs in bipolar disorder and schizophrenia.
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Bipolar disorder (BD, also known as manic-depressive illness) is a severe mood disorder consisting of episodes of mania and depression. The lifetime prevalence of bipolar disorder in the general population is ~1% and the illness is associated with considerable morbidity and a high lifetime risk of suicide (Merikangas et al., 2011).