A 246Kb region around SERINC2 (i.e., NKAIN1-SERINC2 region) was enriched with functional genetic SNPs with replicable associations with alcohol dependence across the European-American discovery sample, the Australians, four HapMap populations and two European samples. The association or functional peak SNPs in each of these populations were in high LD with each other or completely overlapped. In a word, the association and functional signals in this region were consistent across these eight samples.
