Finally, we used MiXeR44 to quantify the degree of polygenic overlap between externalizing and addiction risk. These results suggested that the two constructs share a substantial proportion of their influential genetic variants, with significant unique variants remaining for each trait. We believe that these findings, along with evidence that the two latent traits are differentially genetically correlated with certain psychiatric traits, suggest that, despite a high degree of overlap, addiction risk and externalizing retain meaningful unique genetic variance.
