Chunk #48 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Genotyping: The primary data reviewed here is based on assessments of allele frequencies in multiple DNA pools that each contained equal amounts of DNA from 20 individuals of the same racial and phenotype group. Each DNA pool was assessed on four sets of four arrays, two from “100k” and two from “500k” Affymetrix microarray sets. We also document some of the features of assessments using “1M SNP” Affymetrix 6.0 arrays.