Consistent with a major role for cadherins in the response to cocaine, seven transmembrane cadherins (Celsr) were identified in clusters i and ii. Genes encoding adenylate cyclases appeared in Clusters i, ii, and iii. On the other hand, the majority of genes encoding the β- and γ-subunits of the heterotrimeric G-proteins fell into cluster v (sustained decrease). The few genes whose expression is uniquely regulated in Withdrawal are of special interest; these transcripts may provide insight into the biochemical and cell biological alterations underlying reinstatement of drug-seeking behavior, ultimately helping identify potential therapeutic approaches to prevent relapse (Wolf, 2010).
