Chunk #9 — Materials and methods — Methods — Post-analysis information measures

Source

How to deal with the early GWAS data when imputing and combining different arrays is necessary.

Embedded

yes

Text

Let the posterior probability of imputed genotypes be πi=(πi0, πi1, πi2) for subject i, and the expected dosage for the genotype counts of the ith individual be E(Xi)=πi1+2πi2. Further, let p denote the population minor allele frequency. Assuming HWE, the MACH r2 is defined by