MS lesions, and reduced remyelination in spinal cord vs deep white matter75–80. However, white matter OL lineage cells are more intrinsically regulated vs those in the gray matter, as transplantations into the adult mouse cerebral cortex revealed that white matter-derived cells differentiated into mature OLs in both niches with equal efficiency, whereas gray matter-derived cells did not75. Moreover, a distinct OL population (‘peri-neuronal OL’) has been identified in gray matter regions81.
