Genetic correlations range from −1 to +1, where the sign indicates that the same genetic factors are contributing to variation in the target traits in opposite or same directions, respectively. The LDSC intercept for the genetic covariance provides evidence about sample overlap across two traits. SNPs (MAF>0.01) found in the HapMap3 EUR population were used to calculate LD scores. We used the false discovery rate (FDR; Benjamini and Hochberg, 1995) to correct for multiple testing (n=66 tests; q<0.05). Finally, post-hoc analyses examined whether significant differences between two rgs existed, using the jackknife procedure implemented through LDSC (Bulik-Sullivan et al., 2015b).
