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Chunk #3 — Introduction

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Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
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To more definitively establish the contribution of genetic variants to PTSD risk, to examine the genetic overlap between PTSD and other mental disorders and to identify risk loci, the Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) group employed the consortium science approach of aggregating genomic (genome-wide association study (GWAS)) data from multiple contributing groups. In recent years, the consortium approach has delivered groundbreaking results for many complex genetic phenotypes—including height,14 diabetes15 and schizophrenia16—and here we report initial findings on the genetic architecture of PTSD.