Chunk #4 — Results

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Integrative eQTL-based analyses reveal the biology of breast cancer risk loci.

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Next, to gain biologic insights into known breast cancer risk polymorphisms, we hypothesized that the breast cancer risk alleles previously discovered through GWAS are eQTLs. We performed separate cis- and trans- based eQTL analyses for 15 previously identified risk loci in the TCGA breast cancer datasets.