Chunk #8 — Materials and Methods — Genome-wide Association Analyses

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Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study.

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In addition to the ancestral-specific GWAS, we conducted a multi-ancestral meta-analysis to enhance statistical power with a larger sample size. [20,21] The ancestral-specific GWAS results were combined in a fixed-effects sample size-weighted meta-analysis, as done in prior multi-ancestral meta-analyses[22,23], using the METAL program.[24] Meta-analysis results with P<5x10-8 were considered statistically significant.[25]