Chimeric protein-2 interfering with the remodeling of actin skeleton by Rac GTPase system led to the abnormal formation of neurites and growth cones, which is considered one of the important mechanisms of addictive behavior. This research showed that long-term MA addiction caused the methylation changes of CHN2 gene promoter. All of the findings provide a theoretical basis for further exploring the correlations between CHN2 gene methylation with MA addiction.
