Overall, we find 619 human hubs, 78 of which are cancer proteins (13.4% of the total set). This result is comparable to previous reports and confirms that cancer proteins are enriched in hubs when compared to the rest of human proteins (11,12). We also observe that cancer proteins have higher betweenness than the rest of human proteins (P-value <2.2e-16, Wilcoxon test), confirming that they occupy a central position in the network.
